Dennis Gilgallon,
We have found that the validation would generate script for the button's javascript onclick function.
And that function would cause the page postback.
So please try to use this code :
<script runat="server">
protected override void OnInit(EventArgs e)
{
base.OnInit(e);
Uploader1.InsertButton.ValidationGroup = "NoValidation";
}
</script>
Regards,
Terry