This is my web.config's <httpModules> section:
<httpModules>
<add name="CuteEditor.UploadModule" type="CuteEditor.UploadModule,CuteEditor"/>
<add name="ScriptModule" type="System.Web.Handlers.ScriptModule, System.Web.Extensions, Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"/>
</httpModules>
The "ScriptModule" is for the ASP.NET AJAX (+CTP update), I believe (System.Web.Extensions). Other than that ASP.NET AJAX and CTP requirements, there are no modules or handlers configured.
There are also no ISAPI filters that limit the max request size (typically those would be security related ISAPI filters). files <200k still upload correctly, and a 0 byte resx file is still created in my CuteEditor Temp folder when I upload a large file. the resx file is deleted about the same time I get the error message (after a while... timeout)