Yes 100% and its not currently working on IIS7, have you tryed to get this work on IIS7 and asp.net 4.0 ? Visual Studio says:
 AjaxUplader was not setup in web.config file (even its there just like in the link above IIS7 integrated mode)

However the assembly seems to be in place, no compiler error or warning. That i find strange and hard
to trace.

When fireing the code in the browser (any browser) i get pop up API with "unknown error".

i am using <asp:Uploader now instead til i can use ajaxuploader, kinda miss the progress bar.